Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html


Study Counts

Type Study_count
Total_Studies 2269
interventional 1899
Observational 345
Registry 25

Studies over Time

```

Interventional Trials

Intervention Type

intervention_type Study_Count
Device 332
Drug 331
Other 262
Drug|placebo 237
Procedure 188
Behavioral 113
Biological 65
Dietary Supplement|placebo 30
Biological|Drug 27
Device|Other 27
Device|Drug 25
Device|placebo 25
Biological|placebo 23
Dietary Supplement 23
Drug|Other 18
Behavioral|Other 17
Drug|Procedure 17
Device|Procedure 12
Other|placebo 12
Other|Procedure 10
Diagnostic Test 8
Biological|Other 7
placebo|Procedure 6
Biological|Device 5
Biological|Procedure 5
Dietary Supplement|Drug 5
Behavioral|Device 4
Behavioral|Procedure 4
Biological|Drug|placebo 4
Dietary Supplement|Drug|placebo 4
Radiation 4
Combination Product 3
Device|Other|placebo 3
Behavioral|Biological 2
Behavioral|Drug 2
Biological|Drug|Procedure 2
Combination Product|Device 2
Device|Dietary Supplement|Other|Procedure 2
Drug|Other|placebo 2
Genetic 2
placebo 2
Behavioral|Device|Other 1
Behavioral|Device|placebo 1
Behavioral|Dietary Supplement|placebo 1
Behavioral|Drug|Genetic|Other 1
Behavioral|Drug|Other 1
Behavioral|Drug|Other|Procedure 1
Behavioral|Other|Procedure 1
Behavioral|placebo 1
Biological|Device|Drug 1
Combination Product|Other 1
Combination Product|placebo 1
Device|Diagnostic Test 1
Device|Drug|Other 1
Device|Drug|placebo 1
Device|Drug|Procedure 1
Device|Other|placebo|Procedure 1
Device|Other|Procedure 1
Device|Procedure|Radiation 1
Diagnostic Test|Procedure 1
Dietary Supplement|Drug|Other|placebo 1
Dietary Supplement|Other 1
Dietary Supplement|Other|placebo 1
Dietary Supplement|Procedure 1
Drug|Other|Procedure 1
Drug|placebo|Procedure 1
Drug|placebo|Radiation 1
Other|placebo|Procedure 1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Weekly studies for each intervention

Studies by Country

Country Study_Count
United States 620
NA 183
Canada 115
Denmark 85
Korea, Republic of 63
Brazil 59
Taiwan 49
United Kingdom 45
Spain 44
China 42
France 37
Germany 32
Italy 31
Sweden 28
Turkey 27
Thailand 23
Netherlands 22
Norway 22
Switzerland 18
Belgium 16
Finland 16
Japan 15
Egypt 14
India 13
United States|Canada 13
Australia 12
Iran, Islamic Republic of 12
Hong Kong 10
Israel 10
Pakistan 8
Ireland 6
Poland 6
Russian Federation 6
Singapore 6
Mexico 5
Austria 4
Hungary 4
Indonesia 4
Malaysia 4
Portugal 4
United States|United Kingdom 4
Argentina 3
Chile 3
Czechia|Poland 3
France|Germany 3
Jordan 3
South Africa 3
United States|Australia 3
Belgium|France 2
Canada|United Kingdom 2
Cyprus 2
Estonia 2
Germany|Netherlands|United Kingdom 2
Germany|Switzerland 2
Greece 2
Hungary|Poland 2
Lebanon 2
Lithuania 2
New Zealand 2
Philippines 2
Romania 2
Serbia 2
United States|Czechia|Denmark 2
United States|Germany 2
United States|Puerto Rico 2
United States|Puerto Rico|Romania 2
Vietnam 2
Armenia 1
Australia|Austria|Czech Republic|Finland|Germany|Hungary|Israel|Netherlands|New Zealand|Poland|Slovakia|South Africa|Spain|Sweden|Turkey 1
Australia|Canada|Netherlands Antilles 1
Australia|Germany 1
Australia|Taiwan 1
Austria|Belgium|Canada|Czechia|Spain 1
Austria|Belgium|Italy|Norway 1
Austria|Canada|Spain|United Kingdom 1
Austria|France|Germany|Spain 1
Austria|Germany|Sweden 1
Austria|Poland|Spain 1
Belgium|Brazil|Canada|China|Colombia|Costa Rica|Croatia|Czech Republic|Ecuador|Estonia|France|Germany|Greece|Guatemala|Hong Kong|India|Korea, Republic of|Latvia|Lithuania|Netherlands|Panama|Peru|Portugal|Russian Federation|Serbia|Singapore|South Africa|Spain|Sweden|Taiwan|Ukraine|United Kingdom 1
Belgium|Czech Republic|Italy|Poland|Switzerland 1
Belgium|Czechia|Denmark|Hong Kong|Moldova, Republic of 1
Belgium|Czechia|Finland|Germany|Hungary|Spain 1
Belgium|Czechia|Germany|Hungary|Spain|United Kingdom 1
Belgium|Denmark|Germany|Italy|Netherlands|Norway|Spain|Switzerland|Turkey|United Kingdom 1
Belgium|France|Germany|Israel|Italy|Netherlands 1
Belgium|France|United Kingdom 1
Belgium|Germany|Hungary|Italy|Poland 1
Belgium|Netherlands 1
Belgium|Poland 1
Bulgaria|Canada|Croatia|Finland|Germany|Poland|Serbia|South Africa|Sweden 1
Bulgaria|Denmark|Finland|South Africa|Sweden|United Kingdom 1
Bulgaria|Georgia|Germany|Moldova, Republic of 1
Bulgaria|Georgia|Germany|Moldova, Republic of|Romania|United Kingdom 1
Canada|Germany|Netherlands|United Kingdom 1
Canada|Sweden|United Kingdom 1
Costa Rica 1
Czech Republic|Belgium|France|Germany|Netherlands|United Kingdom 1
Czech Republic|France|Germany|Italy|Slovakia|Switzerland 1
Czech Republic|Germany|Poland|United Kingdom 1
Czech Republic|Hungary|Poland 1
Czech Republic|Romania|Slovakia|United Kingdom 1
Czechia 1
Czechia|Denmark|Estonia|Hong Kong|Poland|Romania 1
Denmark|Finland|Sweden 1
Denmark|Germany|Spain|Sweden 1
Denmark|Korea, Republic of|Netherlands|Norway|Spain|Sweden 1
Denmark|Netherlands|United Kingdom 1
Denmark|Sweden 1
Denmark|United Kingdom 1
Estonia|Latvia|Lithuania|Poland|Romania|Ukraine 1
Finland|Poland 1
Finland|United Kingdom 1
France|Germany|Italy|Spain 1
France|Germany|Poland|Spain|United Kingdom 1
France|Netherlands|United Kingdom 1
Germany|Italy|Netherlands 1
Germany|Spain|United Kingdom 1
Germany|Sweden|United Kingdom 1
Germany|United Kingdom 1
Hong Kong|Korea, Republic of|Philippines 1
Hungary|United Kingdom 1
India|Singapore|United Kingdom 1
Israel|United Kingdom 1
Italy|Austria|Bulgaria|Finland|France|Germany|Hungary|Japan|Poland|Portugal|Romania|Slovakia|Spain|Sweden|United Kingdom 1
Italy|Switzerland 1
Myanmar 1
New Zealand|United States|Australia|Canada|Germany|Hungary|Italy|Japan|Lithuania|Portugal|Russian Federation|Serbia|Slovakia|Spain|Sweden 1
Poland|United States|United Kingdom 1
Portugal|Austria|Croatia|Germany|Hungary|Italy|Latvia|Netherlands|Poland|Romania|Slovakia|Spain|United Kingdom 1
Portugal|Spain 1
Puerto Rico 1
Puerto Rico|United States 1
Saudi Arabia 1
Slovenia 1
United States|Argentina|Australia|Belgium|Canada|Czech Republic|Germany|Hungary|Italy|Peru|Poland|Russian Federation|Slovakia|Spain 1
United States|Argentina|Czechia|Denmark|Estonia|Hong Kong|Poland|Romania 1
United States|Australia|Brazil|Bulgaria|Colombia|Croatia|Japan|Korea, Republic of|Serbia|Lithuania|Mexico|New Zealand|Peru|Philippines|Russian Federation|Slovakia|Taiwan|Ukraine 1
United States|Australia|Canada 1
United States|Australia|Canada|Chile|Puerto Rico 1
United States|Australia|Canada|Czechia|Germany|Hungary|Korea, Republic of|Poland|Spain|Sweden|United Kingdom 1
United States|Australia|Canada|Denmark|Estonia|Hong Kong|Lithuania|Romania 1
United States|Australia|Canada|New Zealand 1
United States|Australia|Finland|France|Germany|Italy|Netherlands|United Kingdom 1
United States|Australia|Netherlands 1
United States|Austria|Belgium|France|Germany|Italy|Spain|Sweden|Switzerland|United Kingdom 1
United States|Austria|Czech Republic|Germany|Poland 1
United States|Belgium|Brazil|Canada|Chile|Colombia|France|United Kingdom 1
United States|Belgium|Canada|Czechia|Netherlands|Poland|Spain|United Kingdom 1
United States|Belgium|Hungary|Israel|Italy|Poland|Romania|Serbia 1
United States|Brazil|United Kingdom 1
United States|Bulgaria|Chile|Estonia|Hong Kong|Hungary|Lithuania|Poland|Romania|Russian Federation|South Africa|Spain|Ukraine|United Kingdom 1
United States|Canada|Finland|Germany|Italy|Switzerland 1
United States|Canada|France|Germany|United Kingdom 1
United States|Canada|Germany|Italy|United Kingdom 1
United States|Canada|Hungary|New Zealand|Poland|United Kingdom 1
United States|Canada|Puerto Rico 1
United States|Canada|Sweden 1
United States|Czech Republic|Germany|Italy 1
United States|Czechia|Denmark|Sweden 1
United States|Denmark 1
United States|Denmark|Germany|Hungary|Lithuania|Poland|Romania|Russian Federation|South Africa|Spain|Ukraine|United Kingdom 1
United States|Finland|France|Germany 1
United States|Georgia|Moldova, Republic of|Poland|Ukraine 1
United States|Germany|Greece|Puerto Rico|Romania|Russian Federation|Spain|Sweden 1
United States|Germany|Netherlands|Poland|United Kingdom 1
United States|Greece|Russian Federation|Sweden 1
United States|Poland|Spain|United Kingdom 1
United States|Poland|United Kingdom 1
United States|South Africa 1
United States|Spain|United Kingdom 1

Sites per Study

Site_count Study_Count
1 1347
2 123
3 64
4 48
5 45
6 16
7 16
8 10
9 9
10 15
11 10
12 12
13 13
14 3
15 3
16 7
17 2
18 3
19 5
20 4
21 4
22 6
23 7
24 4
25 4
26 4
27 6
28 5
29 4
30 4
31 2
32 3
33 6
34 6
35 3
36 5
37 1
38 3
40 4
41 1
42 3
43 1
44 5
45 1
47 1
48 4
49 1
51 1
52 1
53 1
55 1
56 2
57 3
59 1
61 1
64 2
65 3
68 1
69 1
72 1
73 2
74 1
79 1
81 1
83 2
85 1
86 1
87 2
88 1
93 1
94 1
96 1
100 2
117 1
124 1
139 1
148 2
171 1
183 1
195 1
507 1
777 1

Phase

Phase Study_Count
N/A 1017
Phase 3 261
Phase 2 214
Phase 4 204
Phase 1 105
Phase 1/Phase 2 54
Phase 2/Phase 3 34
Early Phase 1 10

Number of Arms

Number_of_Arms Count_of_Studies
1 280
2 1081
3 247
4 108
5 17
6 10
7 1
8 2
9 2
10 1
16 1
NA 149

Number of Updates

Count of Versions Count of Studies
1 271
2 294
3 274
4 229
5 202
6 129
7 112
8 76
9 50
10 48
11 45
12 24
13 26
14 13
15 23
16 15
17 8
18 8
19 9
20 6
21 2
22 3
23 2
24 1
25 2
26 3
27 1
28 1
29 2
30 2
31 3
32 1
34 1
35 1
36 1
38 1
40 3
44 1
48 1
67 1
75 3
77 1

Update History Change Type

Change Type Count_of_Changes Count_of_Studies ratio
Study Status 8482 1628 5.210074
Contacts/Locations 3887 1306 2.976263
Recruitment Status 2300 1321 1.741105
None (earliest Version on record) 1899 1899 1.000000
Study Design 1608 1123 1.431879
Outcome Measures 1265 810 1.561728
Sponsor/Collaborators 919 628 1.463376
Arms 895 635 1.409449
Interventions 895 635 1.409449
Eligibility 780 542 1.439114
Study Identification 749 509 1.471513
Study Description 700 507 1.380671
Oversight 600 480 1.250000
References 341 213 1.600939
Conditions 289 225 1.284444
Results 265 265 1.000000
More Information 251 140 1.792857
IPDSharing 182 168 1.083333
Results Submission Events 107 107 1.000000
Documents 67 64 1.046875
Baseline Characteristics 61 53 1.150943
Reported Adverse Events 55 47 1.170213
Participant Flow 47 37 1.270270
2020 Study Status 2 2 1.000000
Quality Control Review has not concludedReturned: May 1 2 2 1.000000

Enrollment Metrics by Phase

Measure Early.Phase.1 N.A Phase.1 Phase.1.Phase.2 Phase.2 Phase.2.Phase.3 Phase.3 Phase.4
Min. 9.00000 1.0000 2.00 10.00000 1.0000 6.0000 18.0000 5.0000
1st Qu. 20.00000 40.0000 15.75 25.50000 51.5000 60.0000 160.0000 60.0000
Median 22.00000 70.0000 31.00 40.00000 100.0000 101.5000 342.5000 111.0000
Mean 33.77778 176.6832 45.70 69.42593 219.9206 161.4412 593.9921 269.0837
3rd Qu. 43.00000 135.0000 56.00 81.25000 216.7500 217.5000 603.5000 196.0000
Max. 86.00000 25876.0000 340.00 457.00000 4000.0000 626.0000 23498.0000 8067.0000

Trial Group Type

group_type Group_Count
Experimental 1771
Active Comparator 1131
Placebo Comparator 510
Other 184
No Intervention 161
NA 149
Sham Comparator 70

Intervention Model

intervention_model Study_Count
Parallel Assignment 1436
Single Group Assignment 327
Crossover Assignment 83
Factorial Assignment 33
Sequential Assignment 10
NA 10

Primary Purpose

primary_purpose Study_Count
Treatment 1600
Supportive Care 66
Prevention 49
Basic Science 46
Other 43
NA 34
Health Services Research 33
Diagnostic 19
Educational/Counseling/Training 4
Screening 4
Device Feasibility 1

Observational Studies

Studies by Country

Country Study_Count
United States 108
NA 38
France 25
Denmark 24
United Kingdom 15
Germany 8
Canada 7
Italy 6
Switzerland 6
China 5
Spain 5
Brazil 4
Egypt 4
Israel 4
Japan 4
Korea, Republic of 4
Sweden 4
Australia 3
Belgium 3
Hong Kong 3
Netherlands 3
Norway 3
Turkey 3
United States|Canada 3
Germany|Switzerland 2
South Africa 2
United States|Australia|New Zealand|United Kingdom 2
Argentina|Colombia|Korea, Republic of|Malaysia|Mexico|Philippines|Russian Federation|Thailand|Venezuela|Vietnam 1
Australia|Canada|France 1
Austria|Canada|France|Korea, Republic of|United Kingdom 1
Austria|France|Germany|Italy|United Kingdom 1
Austria|France|Germany|Netherlands|Spain|United Kingdom 1
Austria|Germany 1
Austria|Germany|Spain 1
Belarus 1
Belgium|Canada|France|Spain|United Kingdom 1
Belgium|Denmark|Finland|Germany|Netherlands|Spain|United Kingdom 1
Belgium|Finland|Germany|Netherlands|Norway|Spain|Switzerland|United Kingdom 1
Belgium|Finland|Spain|United Kingdom 1
Belgium|France 1
Belgium|France|Germany|Greece|Italy|Netherlands|Norway|Spain|Sweden|Switzerland|Turkey|United Kingdom 1
Belgium|Italy|Netherlands|Norway|United Kingdom 1
Belgium|Netherlands 1
Canada|Sweden 1
Colombia 1
Croatia|Czech Republic|Estonia|Russian Federation|Slovakia 1
Finland 1
France|Germany|Netherlands|Switzerland 1
France|Germany|Switzerland 1
France|Netherlands|Norway|Spain 1
Germany|Italy|United Kingdom 1
Germany|Netherlands|Poland 1
Germany|Netherlands|Poland|United Kingdom 1
Germany|Slovakia 1
Germany|Sweden 1
Hungary 1
India|Italy|Korea, Republic of 1
Italy|Luxembourg 1
Norway|Sweden 1
Philippines 1
Portugal 1
Romania 1
Russian Federation 1
Slovenia 1
Taiwan 1
Thailand 1
United States|Australia|Austria|Belgium|Canada|Germany|Hong Kong|Korea, Republic of|Malaysia|New Zealand|Singapore|Switzerland|Thailand|United Kingdom 1
United States|Australia|Italy|South Africa|United Kingdom 1
United States|Austria|Canada|France|Germany|Ireland|Netherlands|New Zealand|United Kingdom 1
United States|France|Germany|Ireland|Netherlands|Spain 1
United States|France|Spain|United Kingdom 1
United States|Germany 1
United States|Italy|Poland 1
United States|United Kingdom 1

Sites per Study

Site_count Study_Count
1 239
2 18
3 15
4 12
5 15
6 11
7 3
8 9
9 2
10 1
11 2
12 2
13 1
14 2
15 2
16 1
18 1
20 2
22 1
36 1
62 1
85 1
96 1
244 1
320 1

Number of Updates

Count of Versions Count of Studies
1 64
2 65
3 53
4 34
5 29
6 19
7 12
8 11
9 13
10 10
11 6
12 3
13 4
14 5
15 3
16 1
18 2
19 2
20 1
21 1
23 1
24 2
33 2
37 1
41 1

Update History Change Type

Change Type Count_of_Changes Count_of_Studies ratio
Study Status 1404 281 4.996441
Contacts/Locations 583 222 2.626126
None (earliest Version on record) 345 345 1.000000
Recruitment Status 342 218 1.568807
Study Design 244 164 1.487805
Outcome Measures 145 108 1.342593
Eligibility 127 89 1.426966
Sponsor/Collaborators 113 81 1.395062
Study Description 100 70 1.428571
Groups 97 70 1.385714
Interventions 97 70 1.385714
Study Identification 86 64 1.343750
Oversight 72 65 1.107692
Conditions 56 46 1.217391
More Information 25 8 3.125000
IPDSharing 23 21 1.095238
References 20 15 1.333333
Results 19 19 1.000000
Documents 6 6 1.000000
Baseline Characteristics 3 3 1.000000
Results Submission Events 3 3 1.000000
Reported Adverse Events 2 1 2.000000
Participant Flow 1 1 1.000000

Enrollment Metrics

Measure Observational
Min 1.000
1st Qu 50.000
Median 125.000
Mean 1390.207
3rd Qu 262.500
Max 178214.000

Observation Model

observational_model Study_Count
Cohort 214
Case-Only 39
Case-Control 24
Case Control 23
Other 19
NA 19
Case-Crossover 2
Ecologic or Community 2
Case Control, Natural History 1
Family-Based 1
Natural History 1

Time Perspective

time_perspective Study_Count
Prospective 237
Retrospective 49
Cross-Sectional 38
NA 10
Other 9
Longitudinal, Retrospective 1
Longitudinal, Retrospective/Prospective 1

Registries

Studies by Country

Country Study_Count
NA 5
China 3
Denmark 3
Turkey 2
United Kingdom 2
United States 2
Australia|Korea, Republic of 1
Austria 1
Belgium|Germany|Israel 1
France 1
Japan 1
Netherlands 1
Sweden 1
Thailand 1

Sites per Study

Site_count Study_Count
1 18
2 3
4 3
8 1

Number of Updates

Count of Versions Count of Studies
1 8
2 4
3 2
4 3
5 2
6 2
8 1
10 1
11 1
12 1

Update History Change Type

Change Type Count_of_Changes Count_of_Studies ratio
Study Status 72 17 4.235294
None (earliest Version on record) 25 25 1.000000
Contacts/Locations 23 11 2.090909
Recruitment Status 18 12 1.500000
Study Design 14 9 1.555556
Outcome Measures 4 4 1.000000
Oversight 4 3 1.333333
Study Description 4 3 1.333333
Study Identification 4 4 1.000000
Sponsor/Collaborators 2 1 2.000000
Conditions 1 1 1.000000
Groups 1 1 1.000000
Interventions 1 1 1.000000

Enrollment Metrics

Measure Registries
Min 2.0
1st Qu 80.0
Median 350.0
Mean 17688.8
3rd Qu 848.0
Max 288276.0

Registry Model

observational_model Study_Count
Cohort 15
Case-Control 3
Case-Crossover 2
Case Control 2
Other 2
Ecologic or Community 1

Time Perspective

time_perspective Study_Count
Prospective 17
Other 5
Cross-Sectional 3

Follow-up

target_duration Study_Count
2 Years 4
5 Years 4
1 Year 3
10 Years 2
12 Months 2
1 Day 1
12 Years 1
14 Days 1
15 Years 1
2 Months 1
20 Years 1
24 Months 1
3 Months 1
8 Weeks 1
90 Days 1